For UK Healthcare Professionals Only


Adverse events should be reported. Reporting forms and information can be found at: yellowcard.mhra.gov.uk
Adverse events should also be reported to Zydus Pharmaceuticals UK Ltd on 0800 9956034.

Zyduco-XL


Introducing Zyduco XL, A Cost-Effective, Bioequivalent Alternative to Mezavant® XL for mild to moderate ulcerative colitis treatment 1–7


Please click here for Zyduco® XL prescribing information


Zyduco® XL (Mesalazine 1200mg) offers Integrated Care Boards (ICBs) a significant opportunity to reduce drug expenditure without compromising on effectiveness or efficacy to you or your patient1-6.


  • Proven Bioequivalence:
  • Licensed and demonstrably bioequivalent to the market leader Mezavant® XL3.


  •  Immediate Cost Savings:
  • Delivers a 30% saving on both the standard 60-tablet blister pack and also the new larger 120-tablet pack, optimising your budget and reducing carbon footprint through less frequent dispensing1,4-6.


  • Substantial System-Wide Savings:
  • Based on an average ICB, a 100% conversion could save over £73,000 per annum4-6.


  • Larger 120-tablet pack:
  • Larger pack size provides help towards CCG/ICB waste management objectives7.


  • Dedicated Transition Support:
  • Zydus UK provides full support to ensure a smooth, managed switch, including stock management and communication resources, with Zyduco XL also available through all mainline wholesalers.

Zyduco® XL Cost Saving Calculator 8-9

Resources for HCPs

References


1. Zyduco® XL. Summary of Product Characteristics. https://www.medicines.org.uk/emc/product/100638/smpc [Accessed April 2026]

2. Mezavant® XL 1200 mg. Summary of Product Characteristics. https://www.medicines.org.uk/emc/product/6154/smpc [Accessed

April 2026]

3. Data on File (D1). Zydus Pharmaceuticals UK Ltd. [Bioequivalence data]

4. Data on File (D2). Zydus Pharmaceuticals UK Ltd. [Cost Calculation Tool]

5. https://dmd-browser.nhsbsa.nhs.uk/ [Accessed April 2026]

6. https://www.drugtariff.nhsbsa.nhs.uk/#/00883669-DC/DC00883665/Home [Accessed April 2026]

7. https://www.england.nhs.uk/long-read/green-plan-guidance/ [Accessed April 2026]

8.NHS DM+D browser. services.nhsbsa.nhs.uk/dmd-browser/search

9.NHS Business Services Agency. Drug Tariff Category C price. NHS Electronic Drug Tariff. www.drugtariff.nhsbsa.nhs.uk
Savings are based on April 2026 Drug Tariff


Disclaimers:


This calculator calculates the potential cost difference for a ICB/Sub-ICBs/PCN - if Zydus Zyduco branded Mesalzine 1200mg MR Tabs are prescribed instead of Mezavant XL.

This calculator uses the pack usage information provided, and then uses current DM & D NHS list prices and Drug Tariff reimbursement prices to calculate the cost difference in prescribing.

Please note this is only an estimation based on current pricing as it is impossible to predict the future pricing of both generic and branded competitors. The source data for this model will be updated when necessary.

This data contains public sector information licensed under the Open Government Licence v3.0.

ZUK/WEB/HPA/25/11/01